Whole Foods is my main-stay grocery store -- when I can't get to Rainbow or to a farmer's market for produce, I end up buying stuff here. You have to be careful - buying all organic can mean you spend a lot more for organic produce flown in from Chile, so just skip it. Try to stick to locally available produce and you'll get better prices on organic.
Most Whole Foods have a pretty good bulk selection -- the 4th/Harrison location has most of what I need, but with a smaller selection of bulk herbs and teas than the Telegraph location. The Potrero Hill store has nothing in bulk -- keep in mind that they do tailor the grocery stores based on the size of the location and the store's expectations of the local demographic.
Jenn A.'s keywords: grocery store, food